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Adjuvant drug therapy
You are viewing BNF. Breast cancer is the most common form of malignancy in women, especially in those aged over 50 years. Established risk factors include age, early onset of menstruation, late menopause, older age at first completed pregnancy, and a family history of breast cancer. The use of oral contraceptives or hormone replacement therapy HRT is also associated with an increased risk of breast cancer. Breast cancer in men is rare. Although risk factors are not fully understood, it may be associated with abnormalities of sex hormone metabolism, including those caused by liver disease or testicular trauma, genetic predisposition, and environmental risk factors such as industrial exposure to chronic heat. Non-invasive breast cancer, also known as ductal carcinoma in situ , is when the cancer remains localised in the ducts. However, in most cases, the cancer is invasive at the time of diagnosis, which means that malignant cells are liable to spread beyond the immediate area of the tumour. Reducing mortality, increasing progression-free and disease-free survival and improving quality of life are the main aims of treatment, and are dependent on the stage of the disease. Surgery and radiotherapy aim to remove the tumour mass, whilst adjuvant drug therapy drug treatment following surgery aims to reduce the risk of disease recurrence and the risk of developing invasive disease.
Neoadjuvant drug therapy
HER2, or human epidermal growth factor receptor 2, is a cancer cell protein which is associated with larger tumours, higher risk of recurrence and poorer clinical outcomes in breast cancer. It is estimated that around patients in England and Wales will now be eligible to receive the drug through routine NHS use. NICE moved to recommend the drug on the basis of clinical data demonstrating that Kadcyla improved progression-free survival compared to trastuzumab alone in patients who saw their tumours shrunk but not eliminated after receiving neoadjuvant therapy with a taxane chemotherapy and HER2-targeted treatment — a population who are at risk of disease re-emergence. We are proud to have worked with the breast cancer community to achieve this milestone, one which represents a step forward in the treatment of this disease. I found your this post while searching for some related information on blog search Its a good post.. Thanks for sharing the post.. It is a great website.. The Design looks very good..
Cyclical breast pain is related to the menstrual cycle and is not associated with specific underlying breast disease. Breast pain - cyclical Last revised in August Summary Have I got the right topic? How up-to-date is this topic? Goals and outcome measures Background information Diagnosis Management Supporting evidence How this topic was developed References.